Blk^em1Hxzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Blk^em1Hxzh
• Name: Blk proto-oncogene, Src family tyrosine kinase; endonuclease-mediated mutation 1, Hai-Xue Zheng
• MGI ID: MGI:8268541
• Gene: Blk Location: Chr14:63610285-63654486 bp, - strand Genetic Position: Chr14, 33.25 cM
• Alliance: Blk^em1Hxzh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 3-9 (approximately 7.8 kb). (J:375901)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Blk Mutation: 33 strains or lines available

References

• Original: J:375901 Li WW, et al., BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation. J Cell Biol. 2024 Feb 5;223(2)
• All: 1 reference(s)