Phenotypes associated with this allele

• Allele Symbol: Armcx1^tm1.2Sgos
• Allele Name: targeted mutation 1.2, Sidney Gospe
• Allele ID: MGI:8262793
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Armcx1^tm1.2Sgos/Armcx1^tm1.2Sgos	involves: C57BL/6J * C57BL/6N * FVB/N	MGI:8286538
ot2	Armcx1^tm1.2Sgos/Y	involves: C57BL/6J * C57BL/6N * FVB/N	MGI:8286539

Genotype
MGI:8286538

hm1

• Allelic Composition: Armcx1^tm1.2Sgos/Armcx1^tm1.2Sgos
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:374863 )

♀ • female mice are viable, healthy and fertile, with no apparent physical or behavioral phenotype or signs of decreased embryo viability

Genotype
MGI:8286539

ot2

• Allelic Composition: Armcx1^tm1.2Sgos/Y
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

normal phenotype

no abnormal phenotype detected ( J:374863 )

♂ • male mice are viable, healthy and fertile, with no apparent physical or behavioral phenotype or signs of embryonic lethality; at 15 months of age, histological analysis shows no significant change in retinal ganglion cell (RGC) soma density at locations proximal, intermediate, and distal to the optic nerve head, while TEM indicates normal RGC axon abundance with no morphological defects in RGC axons or their surrounding myelin sheaths, suggesting absence of RGC degeneration and axonopathy under normal physiological conditions