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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Imp3tm1Tya
targeted mutation 1, Tadashi Yamamoto
MGI:8260941
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Imp3tm1Tya/Imp3tm1Tya B6.129-Imp3tm1Tya MGI:8261280
cn2
 		Cnot3tm1.2Tya/Cnot3tm1.2Tya
Imp3tm1Tya/Imp3tm1Tya
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA MGI:8261282


Genotype
MGI:8261280
hm1
Allelic
Composition		 Imp3tm1Tya/Imp3tm1Tya
Genetic
Background		 B6.129-Imp3tm1Tya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Imp3tm1Tya mutation (0 available); any Imp3 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:374252 )
• mice are born at Mendelian frequency, grow without any obvious abnormalities, and show normal liver histology




Genotype
MGI:8261282
cn2
Allelic
Composition		 Cnot3tm1.2Tya/Cnot3tm1.2Tya
Imp3tm1Tya/Imp3tm1Tya
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1.2Tya mutation (0 available); any Cnot3 mutation (34 available)
Imp3tm1Tya mutation (0 available); any Imp3 mutation (4 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:374252 )

liver/biliary system
abnormal liver sinusoid morphology ( J:374252 )
• misaligned sinusoids

immune system

cardiovascular system
abnormal liver sinusoid morphology ( J:374252 )
• misaligned sinusoids




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory