Phenotypes associated with this allele

• Allele Symbol: Tg(Tagln-lacZ)445Eno
• Allele Name: transgene insertion 445, Eric N Olson
• Allele ID: MGI:8260874
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ece1^tm1Reh/Ece1^tm1Reh Tg(Tagln-lacZ)445Eno/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3036222
cx2	Ednra^tm1Ywa/Ednra^tm1Ywa Tg(Tagln-lacZ)445Eno/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3036217

Genotype
MGI:3036222

cx1

• Allelic Composition: Ece1^tm1Reh/Ece1^tm1Reh; Tg(Tagln-lacZ)445Eno/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal artery morphology ( J:48566 )

• the branchial arch artery patterning abnormalities result in various types of great vessel malformations

persistent ductus caroticus ( J:48566 )

• at E12.5 in approximately 50% of embryos both right and left ductus caroticus remain

persistent right dorsal aorta ( J:48566 )

• at E12.0 - 12.5 and E13.0 - 13.5 the right dorsal aorta remains (6 out of 13 and 6 out of 7)

• at E13.0 the connection of the right dorsal aorta to the abdominal dorsal aorta persists

• in 2 of these embryos right sided dorsal aorta is observed where left arch arteries 4 and 6 and right arch artery 4 regress, while right arch artery 6 and the right dorsal aorta persist and form the major outflow tract from the heart

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (11 out of 13 and 5 out of 7, respectively)

• at E12.0 - 12.5 and E13.0 - 13.5 regression of left arch artery 4 is also seen but not as frequently (7 out of 13 and 4 out of 7, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 in 6 out of 13 embryos right arch artery 6 abnormally persists

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 6 out of 13 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed and the external carotid fails to branch off of arch arteries 3

aberrant origin of the right subclavian artery ( J:48566 )

• the right subclavian artery is missing or has a cervical origin in term embryos as a result of abnormal regression of right arch artery 4

• in term embryos with abnormal regression of right arch artery 4 and normal regression of the right ductus caroticus, the right dorsal aorta persists and the right subclavian artery is missing or originates from the dorsal aorta

double aortic arch ( J:48566 )

• double aortic arch is found in term embryos when both the right and left arch arteries 4 abnormally regress or when left arch artery 6 abnormally regresses

abnormal ascending aorta morphology ( J:48566 )

• at E13.0 some embryos have extra branches from the ascending aorta

persistent truncus arteriosus ( J:48566 )

double outlet right ventricle ( J:48566 )

overriding aortic valve ( J:48566 )

• other outflow tract abnormalities such as overriding aorta, double outlet right ventricle, and persistent truncus arteriosus are observed

craniofacial

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (11 out of 13 and 5 out of 7, respectively)

• at E12.0 - 12.5 and E13.0 - 13.5 regression of left arch artery 4 is also seen but not as frequently (7 out of 13 and 4 out of 7, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 in 6 out of 13 embryos right arch artery 6 abnormally persists

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 6 out of 13 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed and the external carotid fails to branch off of arch arteries 3

embryo

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (11 out of 13 and 5 out of 7, respectively)

• at E12.0 - 12.5 and E13.0 - 13.5 regression of left arch artery 4 is also seen but not as frequently (7 out of 13 and 4 out of 7, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 in 6 out of 13 embryos right arch artery 6 abnormally persists

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 75% (6/8) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 6 out of 13 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed and the external carotid fails to branch off of arch arteries 3

Genotype
MGI:3036217

cx2

• Allelic Composition: Ednra^tm1Ywa/Ednra^tm1Ywa; Tg(Tagln-lacZ)445Eno/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

cardiovascular system

abnormal artery morphology ( J:48566 )

• the branchial arch artery patterning abnormalities result in various types of great vessel malformations

persistent right dorsal aorta ( J:48566 )

• at E12.0 - 12.5 and E13.0 - 13.5 the right dorsal aorta remains (5 out of 6 and 5 out of 5)

• at E13.0 the connection of the right dorsal aorta to the abdominal dorsal aorta persists

• in term embryos with abnormal regression of right arch artery 4 and normal regression of the right ductus caroticus, the right dorsal aorta persists and the right subclavian artery is missing or originates from the dorsal aorta

abnormal pharyngeal arch artery morphology ( J:48566 )

• at E12.5 both right and left ductus caroticus remain in 100% and 83% of embryos respectively

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (4 out of 6 and 2 out of 5, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 6 abnormally persists (4 out of 6 and 3 out of 5)

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 2 out of 6 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed

• at E12.5 the external carotid fails to branch off of arch arteries 3

aberrant origin of the right subclavian artery ( J:48566 )

• the right subclavian artery is missing or has a cervical origin in term embryos as a result of abnormal regression of right arch artery 4

• in term embryos with abnormal regression of right arch artery 4 and normal regression of the right ductus caroticus, the right dorsal aorta persists and the right subclavian artery is missing or originates from the dorsal aorta

double aortic arch ( J:48566 )

• double aortic arch is found in term embryos when both the right and left arch arteries 4 abnormally regress or when left arch artery 6 abnormally regresses

abnormal ascending aorta morphology ( J:48566 )

• at E13.0 some embryos have extra branches from the ascending aorta

persistent truncus arteriosus ( J:48566 )

double outlet right ventricle ( J:48566 )

overriding aortic valve ( J:48566 )

• other outflow tract abnormalities such as overriding aorta, double outlet right ventricle, and persistent truncus arteriosus are observed

craniofacial

abnormal pharyngeal arch artery morphology ( J:48566 )

• at E12.5 both right and left ductus caroticus remain in 100% and 83% of embryos respectively

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (4 out of 6 and 2 out of 5, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 6 abnormally persists (4 out of 6 and 3 out of 5)

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 2 out of 6 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed

• at E12.5 the external carotid fails to branch off of arch arteries 3

embryo

abnormal pharyngeal arch artery morphology ( J:48566 )

• at E12.5 both right and left ductus caroticus remain in 100% and 83% of embryos respectively

abnormal fourth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 4 shows signs of regression including decreased diameter and expression of a transgenic lacZ marker of arterial smooth muscle (4 out of 6 and 2 out of 5, respectively)

• between E11.5 and E13.5 the fourth arch arteries are diminished

abnormal sixth pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

persistent right 6th pharyngeal arch artery ( J:48566 )

• at E12.0 - 12.5 and E13.0 - 13.5 right arch artery 6 abnormally persists (4 out of 6 and 3 out of 5)

• at E13.0 in embryos where the right arch artery 4 regressed the right arch artery 6 persisted

abnormal third pharyngeal arch artery morphology ( J:48566 )

• in E11.5 embryos 50% (2/4) show enlargement of right arch artery 3 and relative narrowing of arch arteries 4 and 6

• this occurred more frequently on the right side (6 out of 8 than on the left 3 out of 8)

• at E12.0 - 12.5 right arch artery 3 is markedly enlarged in 2 out of 6 embryos

• at E12.5 arch arteries 3 become the dominant vessels bilaterally, accepting blood from the outflow tract

• at E12.5 the overall growth of arch arteries 3 toward the cranial direction is delayed

• at E12.5 the external carotid fails to branch off of arch arteries 3