All Phenotypes Atf7ip2<em1Shnk> MGI Mouse

abnormal chromosomal synapsis ( J:360872 )

• in early/mid-pachytene spermatocytes, the removal of gammaH2AX from autosomes is disrupted

• occasional but significant autosomal asynapsis in pachytene spermatocytes, approximately 67% of pachytene nuclei show complete synapsis compared to wild-type spermatocytes which nearly all show complete synapsis

small seminiferous tubules ( J:360872 )

small testis ( J:360872 )

abnormal spermatogenesis ( J:360872 )

• an increase in the relative population of early/mid-pachytene spermatocytes while late pachytene and diplotene spermatocytes are rare and largely depleted indicating that spermatocytes progress through early meiotic prophase but are predominantly eliminated via cell death during the transition from late pachytene to diplotene stages

decreased spermatid number ( J:360872 )

• testes are devoid of haploid spermatids

abnormal X-Y chromosome synapsis during male meiosis ( J:360872 )

• occasionally, the shapes of sex chromosome axes exhibit abnormal configurations, including looped synapsis (bubbles), synapsis with large portions of itself (irregular), and synapsis at ends (circular)

• approximately 26% of pachytene nuclei show abnormal sex chromosome synapsis

arrest of male meiosis ( J:360872 )

• spermatocytes reach the stage when H1T is enriched, the mid-pachytene stage, indicating that spermatocytes are arrested and eliminated in meiotic prophase I

male infertility ( J:360872 )

• males, but not females, are infertile