Atf7ip2^em1Shnk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atf7ip2^em1Shnk
• Name: activating transcription factor 7 interacting protein 2; endonuclease-mediated mutation 1, Satoshi H Namekawa
• MGI ID: MGI:8259262
• Gene: Atf7ip2 Location: Chr16:10010513-10068595 bp, + strand Genetic Position: Chr16, 5.5 cM, cytoband A3
• Alliance: Atf7ip2^em1Shnk page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 17-bp deletion in exon 4 which encodes a portion of the SETDB1-binding domain, resulting in a frameshift mutation. (J:360872)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf7ip2 Mutation: 40 strains or lines available

References

• Original: J:360872 Alavattam KG, et al., ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline. Genes Dev. 2024 Mar 22;38(3-4):115-130
• All: 1 reference(s)