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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iqsec3em1Jwum
endonuclease-mediated mutation 1, Ji Won Um
MGI:8257179
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iqsec3em1Jwum/Iqsec3em1Jwum C57BL/6J-Iqsec3em1Jwum MGI:8257371


Genotype
MGI:8257371
hm1
Allelic
Composition		 Iqsec3em1Jwum/Iqsec3em1Jwum
Genetic
Background		 C57BL/6J-Iqsec3em1Jwum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqsec3em1Jwum mutation (0 available); any Iqsec3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased miniature excitatory postsynaptic current amplitude ( J:373367 )
• the amplitude of miniature excitatory postsynaptic currents (mEPSCs) is reduced in hippocampal CA1 neurons
decreased miniature excitatory postsynaptic current frequency ( J:373367 )
• the frequency of mEPSCs is reduced in hippocampal CA1 neurons
decreased miniature inhibitory postsynaptic current amplitude ( J:373367 )
• the amplitude of miniature inhibitory postsynaptic currents (mIPSCs) is reduced in hippocampal CA1 neurons
decreased miniature inhibitory postsynaptic current frequency ( J:373367 )
• the frequency of miniature inhibitory postsynaptic currents (mIPSCs) is reduced in hippocampal CA1 neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory