Iqsec3^em1Jwum
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iqsec3^em1Jwum
• Name: IQ motif and Sec7 domain 3; endonuclease-mediated mutation 1, Ji Won Um
• MGI ID: MGI:8257179
• Gene: Iqsec3 Location: Chr6:121349892-121450637 bp, - strand Genetic Position: Chr6, 57.28 cM
• Alliance: Iqsec3^em1Jwum page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 16-bp (TGCGCGCCGTGCTCTA) deletion and 2-bp (GT) insertion near the N-terminal coding region, causing a frameshift and premature translation termination. Western blot analysis from brain confirmed absence of protein. (J:373367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqsec3 Mutation: 51 strains or lines available

References

• Original: J:373367 Kim D, et al., IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus. Biol Psychiatry. 2022 May 1;91(9):821-831
• All: 1 reference(s)