About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rpl26em1Yuehu
endonuclease-mediated mutation 1, Yue Huang
MGI:8255293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rpl26em1Yuehu/Rpl26em1Yuehu C57BL/6J-Rpl26em1Yuehu MGI:8255306
ht2
 		Rpl26em1Yuehu/Rpl26+ C57BL/6J-Rpl26em1Yuehu MGI:8255307


Genotype
MGI:8255306
hm1
Allelic
Composition		 Rpl26em1Yuehu/Rpl26em1Yuehu
Genetic
Background		 C57BL/6J-Rpl26em1Yuehu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl26em1Yuehu mutation (0 available); any Rpl26 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal ribosome biogenesis ( J:367469 )
• disruption of CDK5RAP3 localization within ribosomal complexes in liver
• elevated free RNA content and reduced ribosomal content in liver

growth/size/body
increased body weight ( J:367469 )
• increased body weight and decreased liver/body weight ratio at age 12 weeks

homeostasis/metabolism

liver/biliary system
liver/biliary system phenotype ( J:367469 )
N
• normal liver histology
increased susceptibility to diet-induced hepatic steatosis ( J:367469 )
• larger liver, increased body weight and increased liver/body weight ratio after 12 weeks of HFD




Genotype
MGI:8255307
ht2
Allelic
Composition		 Rpl26em1Yuehu/Rpl26+
Genetic
Background		 C57BL/6J-Rpl26em1Yuehu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl26em1Yuehu mutation (0 available); any Rpl26 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal ribosome biogenesis ( J:367469 )
• disruption of CDK5RAP3 localization within ribosomal complexes in liver
• elevated free RNA content and reduced ribosomal content in liver

growth/size/body
increased body weight ( J:367469 )
• increased body weight and decreased liver/body weight ratio at age 12 weeks

homeostasis/metabolism

liver/biliary system
liver/biliary system phenotype ( J:367469 )
• normal liver histology
increased susceptibility to diet-induced hepatic steatosis ( J:367469 )
• larger liver, increased body weight and increased liver/body weight ratio after 12 weeks of HFD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory