Rpl26^em1Yuehu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rpl26^em1Yuehu
• Name: ribosomal protein L26; endonuclease-mediated mutation 1, Yue Huang
• MGI ID: MGI:8255293
• Synonyms: Rpl26: c.395A>G, RPL26-K132R, Rpl26^Mut
• Gene: Rpl26 Location: Chr11:68792392-68795360 bp, + strand Genetic Position: Chr11, 42.17 cM, cytoband B3
• Alliance: Rpl26^em1Yuehu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Lysine codon 132 (AAG) was targeted for change to arginine (AGG) (p.K132R) using an sgRNA (equivalent to ACAAGTAGGAAAGGAGAA) and an ssODN template with CRISPR/Cas9 technology. In the encoded protein the affected residue changed from one that is subject to UFMylation to one that cannot be UFMylated, which affects lipid metabolism in the liver. (J:367469)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl26 Mutation: 5 strains or lines available

References

• Original: J:367469 Yang S, et al., UFMylation safeguards human hepatocyte differentiation and liver homeostasis by regulating ribosome dissociation. Cell Rep. 2025 May 27;44(5):115686
• All: 1 reference(s)