Phenotypes associated with this allele

• Allele Symbol: Ufsp1^em1Dpmi
• Allele Name: endonuclease-mediated mutation 1, Douglas P Millay
• Allele ID: MGI:8255238
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ufsp1^em1Dpmi/Ufsp1^em1Dpmi	involves: C57BL/6	MGI:8255240

Genotype
MGI:8255240

hm1

• Allelic Composition: Ufsp1^em1Dpmi/Ufsp1^em1Dpmi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:372394 )

• motor neuron axons and nerve terminals are decreased in the neuromuscular junction (NMJ) and the degree of NMJ innervation in fast-twitch type muscle is reduced (defined by overlap of AChR and motor neuron axons), indicating a small decrease of the presynaptic area

muscle

muscle phenotype ( J:372394 )

N • mice show no gross abnormalities up to 1 year, with normal weights of tibialis anterior and soleus muscles, no major structural abnormalities in skeletal muscle with normal cross-sectional areas of myofibers in both fast-twitch and slow-twitch muscles, fiber type composition, and no differences in muscle fibrosis or mitochondria, or in degenerative/regenerative responses, normal grip strength and no functional impairments in contractile indexes of skeletal muscle from in situ measurements