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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ythdc2em2Sky
endonuclease-mediated mutation 2, Scott Keeney
MGI:8250765
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ythdc2em2Sky/Ythdc2em2Sky C57BL/6J-Ythdc2em2Sky MGI:8253256
ht2
 		Ythdc2em2Sky/Ythdc2+ C57BL/6J-Ythdc2em2Sky MGI:8253255


Genotype
MGI:8253256
hm1
Allelic
Composition		 Ythdc2em2Sky/Ythdc2em2Sky
Genetic
Background		 C57BL/6J-Ythdc2em2Sky
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc2em2Sky mutation (0 available); any Ythdc2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:324156 )
N
• surprisingly, homozygotes exhibit normal gonads and fertility in both sexes; adult males show normal testis weight-to-body weight ratios and spermatogenesis with no significant increase in the frequency of TUNEL+ apoptotic cells per seminiferous tubule




Genotype
MGI:8253255
ht2
Allelic
Composition		 Ythdc2em2Sky/Ythdc2+
Genetic
Background		 C57BL/6J-Ythdc2em2Sky
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc2em2Sky mutation (0 available); any Ythdc2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:324156 )
• heterozygotes are viable and exhibit normal fertility




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory