Ythdc2^em2Sky
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ythdc2^em2Sky
• Name: YTH domain containing 2; endonuclease-mediated mutation 2, Scott Keeney
• MGI ID: MGI:8250765
• Synonyms: Ythdc2^WLA
• Gene: Ythdc2 Location: Chr18:44961521-45022782 bp, + strand Genetic Position: Chr18, 23.81 cM
• Alliance: Ythdc2^em2Sky page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutations responsible for the amino acid substitutions of tryptophan with alanine at position 1375 and leucine with alanine at position 1380 (W1375A;L1380A). (J:324156)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdc2 Mutation: 58 strains or lines available

References

• Original: J:324156 Saito Y, et al., YTHDC2 control of gametogenesis requires helicase activity but not m(6)A binding. Genes Dev. 2022 Feb 1;36(3-4):180-194
• All: 1 reference(s)