Phenotypes associated with this allele

• Allele Symbol: Coa3^em1Cecad
• Allele Name: endonuclease-mediated mutation 1, CECAD, University of Cologne
• Allele ID: MGI:8246872
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coa3^em1Cecad/Coa3^em1Cecad	C57BL/6N-Coa3^em1Cecad	MGI:8286383

Genotype
MGI:8286383

hm1

• Allelic Composition: Coa3^em1Cecad/Coa3^em1Cecad
• Genetic Background: C57BL/6N-Coa3^em1Cecad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:354134 )

• mice display a significant increase in serum total cholesterol levels

increased circulating HDL cholesterol level ( J:354134 )

• mice display a significant increase in serum HDL cholesterol levels

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:354134 )

• mitochondria isolated from 60-week-ol brain, liver, and skeletal muscle tissue show a significant reduction in complex IV activity, with no significant change detected in heart

• although liver is the most affected tissue, the reduction in complex IV activity is not to same extent as observed in Cox14^em83Cecad mice

immune system

abnormal innate immunity ( J:354134 )

• liver shows a significant upregulation of Interferon Stimulated Genes (ISGs) but to a lesser extent than in Cox14^em83Cecad mice

liver/biliary system

liver/biliary system phenotype ( J:354134 )

N • mice exhibit no apparent liver pathology: no significant alterations are detected in liver morphology by histochemistry, and serum ALT and AST levels are similar to those in wild-type controls

mortality/aging

mortality/aging ( J:354134 )

N • male and female mice exhibit no significant differences in their life expectancies relative to wild-type controls