Coa3^em1Cecad
Endonuclease-mediated Allele Detail

Summary

• Symbol: Coa3^em1Cecad
• Name: cytochrome C oxidase assembly factor 3; endonuclease-mediated mutation 1, CECAD, University of Cologne
• MGI ID: MGI:8246872
• Synonyms: COA3^Y72C
• Gene: Coa3 Location: Chr11:101168796-101169774 bp, - strand Genetic Position: Chr11, 64.56 cM
• Alliance: Coa3^em1Cecad page

Mutation origin

• Strain of Origin: C57BL/6NRj

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 2 introduced a missense point mutation (A583G) resulting in a single amino change from tyrosine to cysteine at position 72 (Y72C). (J:354134)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coa3 Mutation: 5 strains or lines available

References

• Original: J:354134 Aich A, et al., Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nat Commun. 2024 Aug 12;15(1):6914
• All: 1 reference(s)