Phenotypes associated with this allele

• Allele Symbol: Zfp488^tm1Qrlu
• Allele Name: targeted mutation 1, Q Richard Lu
• Allele ID: MGI:8242623
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp488^tm1Qrlu/Zfp488^tm1Qrlu	involves: 129S6/SvEvTac * C57BL/6	MGI:8242628

Genotype
MGI:8242628

hm1

• Allelic Composition: Zfp488^tm1Qrlu/Zfp488^tm1Qrlu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased oligodendrocyte number ( J:371392 )

• decrease in the number of CC1+-differentiated oigodendrocytes in the spinal cord and corpus callosum at P7 but not P14

abnormal oligodendrocyte differentiation ( J:371392 )

• in culture, fewer isolated oligodendrocyte precursor cells differentiate into mature oligodendrocytes

• however, proliferation is similar to wild-type cells

abnormal myelination ( J:371392 )

• expression analysis indicates a defect in remyelination at 14 and 21 days after injection of lysophosphatidyl-choline to induce demyelination in the corpus callosum

• in addition, EM analysis shows fewer remyelinated axons and thinner myelin

cellular

decreased oligodendrocyte number ( J:371392 )

• decrease in the number of CC1+-differentiated oigodendrocytes in the spinal cord and corpus callosum at P7 but not P14

abnormal oligodendrocyte differentiation ( J:371392 )

• in culture, fewer isolated oligodendrocyte precursor cells differentiate into mature oligodendrocytes

• however, proliferation is similar to wild-type cells