Phenotypes associated with this allele

• Allele Symbol: Cdadc1^em1Jmdn
• Allele Name: endonuclease-mediated mutation 1, Javier M Di Noia
• Allele ID: MGI:8240199
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdadc1^em1Jmdn/Cdadc1^em1Jmdn	Not Specified	MGI:8240313

Genotype
MGI:8240313

hm1

• Allelic Composition: Cdadc1^em1Jmdn/Cdadc1^em1Jmdn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:368532 )

• mice are hypersensitive to gemcitabine and rapidly reach humane endpoints for euthanasia

increased physiological sensitivity to xenobiotic ( J:368532 )

• mice are hypersensitive to gemcitabine, an antimetabolite chemotherapy drug, showing more than 20% weight loss and diarrhea, thrombocytopenia and leukopenia, with highly reduced myeloid and lymphoid cells within the bone marrow and rapidly reach humane endpoints for euthanasia

• however, untreated mice exhibit no physical or health abnormalities

hematopoietic system

hematopoietic system phenotype ( J:368532 )

N • mice exhibit normal blood leukocyte populations

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:368532 )

• mice are hypersensitive to gemcitabine and rapidly reach humane endpoints for euthanasia

reproductive system

reproductive system phenotype ( J:368532 )

N • mice exhibit normal fertility