Cdadc1^em1Jmdn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdadc1^em1Jmdn
• Name: cytidine and dCMP deaminase domain containing 1; endonuclease-mediated mutation 1, Javier M Di Noia
• MGI ID: MGI:8240199
• Synonyms: Cdadc1^- d41
• Gene: Cdadc1 Location: Chr14:59796837-59835408 bp, - strand Genetic Position: Chr14, 31.48 cM, cytoband C3
• Alliance: Cdadc1^em1Jmdn page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeting exon 4 generated a 41 bp deletion. (J:368532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdadc1 Mutation: 29 strains or lines available

References

• Original: J:368532 Rodriguez MM, et al., CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity. Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2424409122
• All: 1 reference(s)