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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sorem1(DIS3L)Adki
endonuclease-mediated mutation 1, Andrzej Dziembowski
MGI:8239627
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dis3lem2Adki/Dis3lem2Adki
Gt(ROSA)26Sorem1(DIS3L)Adki/Gt(ROSA)26Sor+ 		involves: C57BL/6JTar * CBA/WTar MGI:8276781


Genotype
MGI:8276781
cx1
Allelic
Composition		 Dis3lem2Adki/Dis3lem2Adki
Gt(ROSA)26Sorem1(DIS3L)Adki/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dis3lem2Adki mutation (0 available); any Dis3l mutation (49 available)
Gt(ROSA)26Sorem1(DIS3L)Adki mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:365445 )
• at 5 weeks of age, the only mouse born shows no apparent developmental defects and is morphologically indistinguishable from wild-type littermates; Western blot analysis confirmed expression of the full-length human DIS3L protein product, indicating successful rescue of the embryonic lethal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory