Phenotypes associated with this allele

• Allele Symbol: Hs3st6^em2Vnp
• Allele Name: endonuclease-mediated mutation 2, Vaishali N Patel
• Allele ID: MGI:8235789
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hs3st6^em2Vnp/Hs3st6^em2Vnp	C57BL/6-Hs3st6^em2Vnp	MGI:8474515

Genotype
MGI:8474515

hm1

• Allelic Composition: Hs3st6^em2Vnp/Hs3st6^em2Vnp
• Genetic Background: C57BL/6-Hs3st6^em2Vnp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:360826 )

• mice are viable, fertile, grossly normal, and obtained in expected Mendelian ratios; adult mice have no overt kidney phenotype, showing no significant differences in kidney size, histology, glomerular size, or BUN levels relative to wild-type controls

• surprisingly, LC-MS/MS analysis of kidney heparan sulfate (HS) shows no alterations in the composition of disaccharides and 3-O-sulfated tetrasaccharides