Phenotypes associated with this allele

• Allele Symbol: Ntrk1^{tm1.1(NTRK1*)Cat}
• Allele Name: targeted mutation 1.1, Antonio Cattaneo
• Allele ID: MGI:8233844
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk1^tm1.1(NTRK1*)Cat/Ntrk1^tm1.1(NTRK1*)Cat	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:8233863
ht2	Ntrk1^tm1.1(NTRK1*)Cat/Ntrk1^+	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:8233859

Genotype
MGI:8233863

hm1

• Allelic Composition: Ntrk1^{tm1.1(NTRK1*)Cat}/Ntrk1^{tm1.1(NTRK1*)Cat}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:370501 )

• mice die within the first week of life

growth/size/body

slow postnatal weight gain ( J:370501 )

• pups at P0 show normal body size but exhibit a smaller body size at P4

Genotype
MGI:8233859

ht2

• Allelic Composition: Ntrk1^{tm1.1(NTRK1*)Cat}/Ntrk1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

behavior/neurological

impaired spatial working memory ( J:370501 )

• mice show reduced spontaneous alternations in the Y-maze

decreased anxiety-related response ( J:370501 )

• mice exhibit less anxious behavior in the elevated plus maze, spending more time in the open arms than controls

decreased social novelty preference ( J:370501 )

• in the social novelty preference test, in which a new unfamiliar mouse replaces the object into the wire cup, mice do not show a significant preference for the unfamiliar mouse

• however, mice show no differences in the novel object recognition test

hypoalgesia ( J:370501 )

• mice show an inability to sense thermal and chemical noxious stimuli and to respond to innocuous touch

increased chemical nociceptive threshold ( J:370501 )

• intraepidermal injection of capsaicin fails to evoke a prolonged pain sensation

increased mechanical nociceptive threshold ( J:370501 )

• mice show a decrease in the number of attempts to remove the adhesive tape attached to the back in the tape response assay to assess response to innocuous mechanical stimuli

• however, no differences in response to mechanical stimuli applied on the plantar surface of the hindpaw are seen in the von Frey test

increased thermal nociceptive threshold ( J:370501 )

• mice show a decrease in response and in the percentage of responses to cold noxious stimuli induced by acetone application on the hindpaw indicating decreased cold sensitivity

• mice show a reduced response threshold to a noxious high-temperature stimulus

decreased social investigation ( J:370501 )

• during the socialization phase of the three-chamber sociability test, mice show comparable exploration time between the unfamiliar mouse cage and the inanimate object cage, indicating altered sociability compared to controls

endocrine/exocrine glands

anhidrosis ( J:370501 )

• mice exhibit anhidrosis in the pilocarpine-induced sweat assay

• however, mice show normal adrenergic and cholinergic innvervation of sweat glands

integument

anhidrosis ( J:370501 )

• mice exhibit anhidrosis in the pilocarpine-induced sweat assay

• however, mice show normal adrenergic and cholinergic innvervation of sweat glands

abnormal skin sensory neuron innervation pattern ( J:370501 )

• the area and number of PGP9.5-immunoreactive terminals are severely decreased in the glabrous skin and in hairy skin indicating diminished innervation in both glabrous and hairy skin

• however, sympathetic innervation of internal organs, such as stomach, heart, and kidneys, is not affected

nervous system

abnormal skin sensory neuron innervation pattern ( J:370501 )

• the area and number of PGP9.5-immunoreactive terminals are severely decreased in the glabrous skin and in hairy skin indicating diminished innervation in both glabrous and hairy skin

• however, sympathetic innervation of internal organs, such as stomach, heart, and kidneys, is not affected

abnormal dorsal root ganglion morphology ( J:370501 )

• while mice show no differences in the total dorsal root ganglia (DRG) cell number, TRPV1+ and IB4+ subsets of DRG neurons, essential for pain sensations, are reduced

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory neuropathy type 4		DOID:0070146	OMIM:256800	J:370501