Ntrk1tm1.1(NTRK1*)Cat
Targeted Allele Detail
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Symbol: |
Ntrk1tm1.1(NTRK1*)Cat |
Name: |
neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Antonio Cattaneo |
MGI ID: |
MGI:8233844 |
Synonyms: |
TrkAR649W |
Gene: |
Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
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Alliance: |
Ntrk1tm1.1(NTRK1*)Cat page
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Human NTRK1 cDNA cassette harboring the missense C to T mutation at the 1945 position which results in an arginine to tryptophan substitution at amino acid 649, polyA and loxP-flanked neomycin selection cassette replaced the mouse exon 1 locus. The neomycin selection cassette was removed via cre-mediated recombination. The R649W missense mutation, located in the tyrosine kinase domain (TKD), has been identified in patients with Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV).
(J:370501)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ntrk1 Mutation: |
58 strains or lines available
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Original: |
J:370501 Pacifico P, et al., Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV. Hum Mol Genet. 2023 Apr 6;32(8):1380-1400 |
All: |
1 reference(s) |
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