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Ntrk1tm1.1(NTRK1*)Cat
Targeted Allele Detail
Summary
Symbol: Ntrk1tm1.1(NTRK1*)Cat
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Antonio Cattaneo
MGI ID: MGI:8233844
Synonyms: TrkAR649W
Gene: Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Alliance: Ntrk1tm1.1(NTRK1*)Cat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:370501
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHuman NTRK1 cDNA cassette harboring the missense C to T mutation at the 1945 position which results in an arginine to tryptophan substitution at amino acid 649, polyA and loxP-flanked neomycin selection cassette replaced the mouse exon 1 locus. The neomycin selection cassette was removed via cre-mediated recombination. The R649W missense mutation, located in the tyrosine kinase domain (TKD), has been identified in patients with Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV). (J:370501)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  58 strains or lines available
References
Original:  J:370501 Pacifico P, et al., Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV. Hum Mol Genet. 2023 Apr 6;32(8):1380-1400
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/05/2025
MGI 6.24
The Jackson Laboratory