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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plscr5em1Wagq
endonuclease-mediated mutation 1, Guoqiang Wan
MGI:8220012
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plscr5em1Wagq/Plscr5em1Wagq involves: C57BL/6 MGI:8220021
ht2
 		Plscr5em1Wagq/Plscr5+ involves: C57BL/6 MGI:8220030


Genotype
MGI:8220021
hm1
Allelic
Composition		 Plscr5em1Wagq/Plscr5em1Wagq
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plscr5em1Wagq mutation (0 available); any Plscr5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:368539 )
N
• no defects in vestibular function at 7 months of age
decreased inner hair cell stereocilia number ( J:368539 )
• degeneration of the shortest-row stereocilia at 3 months of age
decreased outer hair cell stereocilia number ( J:368539 )
• complete loss of steriocilia at the basal turn in 2 month old mice
• by 3 months of age, loss is increased at the basal turn and middle turn
• degeneration of the shortest-row stereocilia at 3 months of age
cochlear outer hair cell degeneration ( J:368539 )
• lost at high frequency (32 kHz) in 5 and 8 month old mice
abnormal cochlear hair cell physiology ( J:368539 )
• impaired externalization of phosphatidylserine in cochlear hair cells
abnormal auditory brainstem response waveform shape ( J:368539 )
• ABR peak 1 amplitudes are reduced at all cochlear frequencies
increased or absent distortion product otoacoustic emission threshold ( J:368539 )
• elevated at higher cochlear frequencies at 1 and 4 months of age
• by 8 months of age mice display profound hearing loss across all cochlear frequencies
impaired hearing ( J:368539 )
• by 8 months of age mice display profound hearing loss across all cochlear frequencies

nervous system
decreased inner hair cell stereocilia number ( J:368539 )
• degeneration of the shortest-row stereocilia at 3 months of age
decreased outer hair cell stereocilia number ( J:368539 )
• complete loss of steriocilia at the basal turn in 2 month old mice
• by 3 months of age, loss is increased at the basal turn and middle turn
• degeneration of the shortest-row stereocilia at 3 months of age
cochlear outer hair cell degeneration ( J:368539 )
• lost at high frequency (32 kHz) in 5 and 8 month old mice
abnormal cochlear hair cell physiology ( J:368539 )
• impaired externalization of phosphatidylserine in cochlear hair cells




Genotype
MGI:8220030
ht2
Allelic
Composition		 Plscr5em1Wagq/Plscr5+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plscr5em1Wagq mutation (0 available); any Plscr5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear outer hair cell degeneration ( J:368539 )
• less severe degeneration at 8 months of age than in homozygous mutant mice
impaired hearing ( J:368539 )
• mild hearing loss from 1 to 8 months of age

nervous system
cochlear outer hair cell degeneration ( J:368539 )
• less severe degeneration at 8 months of age than in homozygous mutant mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory