Plscr5^em1Wagq
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plscr5^em1Wagq
• Name: phospholipid scramblase family, member 5; endonuclease-mediated mutation 1, Guoqiang Wan
• MGI ID: MGI:8220012
• Gene: Plscr5 Location: Chr9:92074989-92091825 bp, + strand Genetic Position: Chr9, 48.33 cM
• Alliance: Plscr5^em1Wagq page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using a guide RNA (5'-GTA GCT CGA GGA AGA AAC CC-3') downstream from the second ATG created a 4 bp deletion. (J:368539)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plscr5 Mutation: 18 strains or lines available

References

• Original: J:368539 Gong S, et al., The phospholipid scramblase PLSCR5 is regulated by POU4F3 and required for hair cell stereocilia homeostasis and auditory functions. J Genet Genomics. 2025 Mar 9
• All: 1 reference(s)