All Phenotypes Ccdc178<em1Wli> MGI Mouse

abnormal sperm flagellum morphology ( J:367061 )

• mice are defective in the biogenesis of sperm flagella at stages VI to VIII of the seminiferous epithelium

abnormal sperm axoneme morphology ( J:367061 )

• disruption of the 9 + 2 microtubule structures

• the manchette is present and bound to the caudal region of the elongated spermatid head but shows detachment from the head to the tail at steps 10-13 of spermiogenesis

oligozoospermia ( J:367061 )

• dramatic reduction in sperm count

abnormal sperm head morphology ( J:367061 )

• elongated spermatid heads show abnormalities starting from step 11 and turning to clear at step 16 of spermiogenesis

• disrupted/abnormal sperm head shaping

abnormal acroplaxome morphology ( J:367061 )

• spermatids show expanded acroplaxome spaces

detached acrosome ( J:367061 )

abnormal spermatid morphology ( J:367061 )

• disruption and disorganization of the F-actin structure in spermatids at steps 11-16

abnormal manchette morphology ( J:367061 )

• elongated spermatids show the absence of manchette microtubules

abnormal manchette assembly ( J:367061 )

• disruption of manchette assembly

elongated manchette ( J:367061 )

• the manchette is present and bound to the caudal region of the elongated spermatid head but shows abnormal elongation at steps 10-13 of spermiogenesis

abnormal ectoplasmic specialization morphology ( J:367061 )

• spermatids show disrupted actin bundles surrounding the elongated spermatid nucleus within the apical ectoplasmic specialization structures

small testis ( J:367061 )

abnormal spermiogenesis ( J:367061 )

abnormal intramanchette transport ( J:367061 )

male infertility ( J:367061 )