All Phenotypes Gpr45<em1Zz> MGI Mouse

obese ( J:367505 )

• both males and females gain more weight from 6 weeks of age and obesity is fully developed at 12 weeks of age

• housing at thermoneutrality does not blunt, but rather further aggravates, the extent of obesity compared to those housed at room temperature

• pair-feeding rescues the obesity phenotype

enlarged liver ( J:367505 )

• 12-week-old mice exhibit large, pallid livers

increased liver weight ( J:367505 )

• increases in liver weight in 12-week-old mice

abnormal adipose tissue amount ( J:367505 )

• adipose tissues of 12-week-old mice are increased in size

increased brown adipose tissue amount ( J:367505 )

• 12-week-old mice show increased size of interscapular brown adipose tissue (iBAT)

increased white adipose tissue amount ( J:367505 )

• 12-week-old mice show increased size of epididymal white adipose tissue (eWAT) and inguinal white adipose tissue (iWAT)

increased fat cell size ( J:367505 )

• adipocytes are enlarged indicating hypertrophy

polyphagia ( J:367505 )

• 5-week-old mice show increased hyperphagia

• daily food intake fluctuates, with a consistent increase seen from 40 days of age, and the cumulative food intake significantly increases from 37 days age, when body weight is similar to wild-type littermates

• after the onset of hyperphagia, body weight begins to increase at 42 days of age

• mice pair-fed with the same amount of food from 5 weeks of age show no difference in body weight from controls after 3 weeks of pair-feeding, indicating that hyperphagia causes the obesity phenotype

• treatment with the MC4R agonist setmelanotide reduces food intake

homeostasis/metabolism phenotype ( J:367505 )

N	• mice maintain their core body temperature very well during cold stress in the absence of food

increased fasting circulating glucose level ( J:367505 )

• fasting blood glucose levels are increased at 12 weeks of age

• however, fasting insulin levels are normal at 12 weeks of age

• pair-feeding rescues the diabetes phenotype

increased circulating cholesterol level ( J:367505 )

• increase in blood cholesterol

• however, no change in blood triglycerides

increased respiratory quotient ( J:367505 )

• respiratory exchange ratio (RER) is elevated in 5-week-old mice, suggesting a preference for carbohydrates as a fuel source

• however, no difference in heat production and physical activities are seen

impaired glucose tolerance ( J:367505 )

• glucose intolerance is seen in 12-week-old mice

insulin resistance ( J:367505 )

• insulin resistance is seen in 12-week-old mice

increased liver triglyceride level ( J:367505 )

• increase in liver triglyceride levels in 12-week-old mice

enlarged liver ( J:367505 )

• 12-week-old mice exhibit large, pallid livers

increased liver weight ( J:367505 )

• increases in liver weight in 12-week-old mice

increased liver triglyceride level ( J:367505 )

• increase in liver triglyceride levels in 12-week-old mice

hepatic steatosis ( J:367505 )

• mice show an abundance of stored lipids in the liver

• pair-feeding rescues the fatty-liver phenotype

pale liver ( J:367505 )

• 12-week-old mice exhibit pallid livers

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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