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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adcy3m1Btlr
mutation 1, Bruce Beutler
MGI:8215533
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adcy3m1Btlr/Adcy3m1Btlr C57BL/6J-Adcy3m1Btlr MGI:8216709
cx2
 		Adcy3m1Btlr/Adcy3m1Btlr
Gpr45em1Zz/Gpr45em1Zz 		C57BL/6J-Gpr45em1Zz Adcy3m1Btlr MGI:8216711


Genotype
MGI:8216709
hm1
Allelic
Composition		 Adcy3m1Btlr/Adcy3m1Btlr
Genetic
Background		 C57BL/6J-Adcy3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy3m1Btlr mutation (0 available); any Adcy3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
polyphagia ( J:367505 )
• mice are hyperphagic

growth/size/body
obese ( J:367505 )
• mice are severely obese




Genotype
MGI:8216711
cx2
Allelic
Composition		 Adcy3m1Btlr/Adcy3m1Btlr
Gpr45em1Zz/Gpr45em1Zz
Genetic
Background		 C57BL/6J-Gpr45em1Zz Adcy3m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy3m1Btlr mutation (0 available); any Adcy3 mutation (43 available)
Gpr45em1Zz mutation (0 available); any Gpr45 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
polyphagia ( J:367505 )
• mice are hyperphagic, but not more severely than in single mutants

growth/size/body
obese ( J:367505 )
• mice are obese, but not more severely than in single mutants

homeostasis/metabolism
hyperglycemia ( J:367505 )
• mice are hyperglycemic, but hyperglycemia is not more severe than in single mutants

liver/biliary system
hepatic steatosis ( J:367505 )
• mice exhibit liver steatosis, but steatosis is not more severe than in single mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory