mortality/aging
• although present at Mendelian ratios until E9.5, all homozygous embryos are resorbed by E10.5; no live homozygous mice are recovered from heterozygous intercrosses
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embryo
• embryos exhibit severe growth retardation by E9.5
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• at E9.5, but not at E8.5, most embryos exhibit a significant reduction in crown to tail length relative to wild-type controls
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growth/size/body
• embryos exhibit severe growth retardation by E9.5
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• at E9.5, but not at E8.5, most embryos exhibit a significant reduction in crown to tail length relative to wild-type controls
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