Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr)GwNpln
• Allele Name: transgene insertion Gw, Nicolas Pilon
• Allele ID: MGI:8215438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Gata4-RFP)2Vigr/Tg(Gata4-RFP)2Vigr Tg(Tyr)GwNpln/Tg(Tyr)GwNpln	FVB/N-Tg(Gata4-RFP)2Vigr Tg(Tyr)GwNpln	MGI:8217396

Genotype
MGI:8217396

cx1

• Allelic Composition: Tg(Gata4-RFP)2Vigr/Tg(Gata4-RFP)2Vigr; Tg(Tyr)GwNpln/Tg(Tyr)GwNpln
• Genetic Background: FVB/N-Tg(Gata4-RFP)2Vigr Tg(Tyr)GwNpln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:368544 )

♀

abnormal adipose tissue distribution ( J:368544 )

♀ • in lean and overweight females at age 6 months

increased fat cell size ( J:368544 )

♀ • in lean and overweight females

behavior/neurological

behavior/neurological phenotype ( J:368544 )

♀N • normal ambulatory activity

increased food intake ( J:368544 )

♀ • in lean and overweight females at age 4 and 6 months

cellular

oocyte degeneration ( J:368544 )

♀ • decreased number of viable oocytes

increased endoplasmic reticulum stress ( J:368544 )

♀ • in lean and overweight females at age 6 months

digestive/alimentary system

abnormal anogenital distance ( J:368544 )

♀ • decreased anogenital distance in juveniles

endocrine/exocrine glands

decreased corpora lutea number ( J:368544 )

♀

increased atretic ovarian follicle number ( J:368544 )

♀ • in overweight females

growth/size/body

increased body weight ( J:368544 )

♀ • 35% weight gain at age 29 weeks in less than half of females

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:368544 )

♀N • normal energy expenditure

♀N • normal plasma leptin levels

increased circulating insulin level ( J:368544 )

♀ • in lean and overweight females at age 6 months

increased respiratory quotient ( J:368544 )

♀

insulin resistance ( J:368544 )

♀ • in overweight females at age 6 months

mortality/aging

perinatal lethality, incomplete penetrance ( J:368544 )

♀

reproductive system

oocyte degeneration ( J:368544 )

♀ • decreased number of viable oocytes

abnormal anogenital distance ( J:368544 )

♀ • decreased anogenital distance in juveniles

decreased corpora lutea number ( J:368544 )

♀

increased atretic ovarian follicle number ( J:368544 )

♀ • in overweight females

delayed vaginal opening ( J:368544 )

♀

prolonged diestrus ( J:368544 )

♀ • in overweight females

abnormal estrus ( J:368544 )

♀ • fewer cycles

♀ • increased interval between first estrus and onset of regular cycles

short estrus ( J:368544 )

♀ • in overweight females

short proestrus ( J:368544 )

♀ • in overweight females

increased miscarriage rate ( J:368544 )

♀

reduced female fertility ( J:368544 )

♀ • smaller litter in ~41% of females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic ovary syndrome		DOID:11612	OMIM:184700	J:368544