Phenotypes associated with this allele

• Allele Symbol: Nectin4^em1Jaa
• Allele Name: endonuclease-mediated mutation 1, An-Soo Jang
• Allele ID: MGI:8213563
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nectin4^em1Jaa/Nectin4^em1Jaa	involves: C57BL/6N	MGI:8213564

Genotype
MGI:8213564

hm1

• Allelic Composition: Nectin4^em1Jaa/Nectin4^em1Jaa
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:336809 )

• show reduced airway hyperresponsiveness in an OVA-induced asthma model with lower numbers of total cells, macrophages, eosinophils, neutrophils, and lymphocytes in BAL fluid

• show reduced type 2 cytokine expression and lower levels of IL-4, IL-13, and Th1 and Th2 cytokines in BAL fluid in an OVA-induced asthma model

• in an OVA-induced asthma model lung inflammation scores are 40% lower