Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Romo1)#Xiwa
• Allele Name: transgene insertion, Xianhua Wang
• Allele ID: MGI:8210962
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Romo1)#Xiwa/0	involves: C57BL/6J	MGI:8210979

Genotype
MGI:8210979

tg1

• Allelic Composition: Tg(CAG-Romo1)#Xiwa/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:367536 )

• inactivation of aconitase in response to H2O2 treatment in mitochondria from heart and the liver is attenuated compared to wild-type mitochondria

• 93%, 98%, 98%, and 71% of redox altered cysteines are switched to a more reductive state in mitochondria from the heart, skeletal muscle, liver, and brain, respectively

• augmented Ca2+ retention capacity in mitochondria from the heart, liver, and skeletal muscle indicating delayed permeability transition pore opening

• in older mice the majority of oxidized cysteines are reversed to a more reductive state

homeostasis/metabolism

abnormal circulating lipoprotein level ( J:367536 )

• decreased low density lipoprotein levels in aged mice

decreased circulating alanine transaminase level ( J:367536 )

• in aged mice

decreased circulating aspartate transaminase level ( J:367536 )

• in aged mice

increased oxygen consumption ( J:367536 )

• increase in both ATP-coupled and maximal respiratory rates in mitochondria from the heart and liver

behavior/neurological

increased grip strength ( J:367536 )

• attenuation of age-related decrease in grip strength

cardiovascular system

increased cardiac muscle contractility ( J:367536 )

• reversal of age-associated decline in cardiac contractile function as indexed by ejection fraction and fractional shortening with no sign of cardiac hypertrophy at old versus young age

hematopoietic system

decreased neutrophil cell number ( J:367536 )

• in aged mice indicating a decrease in age related inflammation

decreased monocyte cell number ( J:367536 )

• in aged mice indicating a decrease in age related inflammation

liver/biliary system

abnormal liver physiology ( J:367536 )

• markers of liver damage are largely repressed in aged mice compared to age-matched wild-type controls

immune system

decreased neutrophil cell number ( J:367536 )

• in aged mice indicating a decrease in age related inflammation

decreased monocyte cell number ( J:367536 )

• in aged mice indicating a decrease in age related inflammation

muscle

increased cardiac muscle contractility ( J:367536 )

• reversal of age-associated decline in cardiac contractile function as indexed by ejection fraction and fractional shortening with no sign of cardiac hypertrophy at old versus young age

abnormal muscle morphology ( J:367536 )

• attenuation of age-related muscle atrophy