Phenotypes associated with this allele

• Allele Symbol: Romo1^tm1Xiwa
• Allele Name: targeted mutation 1, Xianhua Wang
• Allele ID: MGI:8210928
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Romo1^tm1Xiwa/Romo1^tm1Xiwa	involves: 129S4/SvJae * C57BL/6	MGI:8211167
cn2	Myl2^tm1(cre)Krc/Myl2^+ Romo1^tm1Xiwa/Romo1^tm1Xiwa	involves: 129S4/SvJae * C57BL/6	MGI:8211166

Genotype
MGI:8211167

cn1

• Allelic Composition: Romo1^tm1Xiwa/Romo1^tm1Xiwa
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:367536 )

• oxidative shift in the cysteinome in mitochondria in the liver in mice injected with AAV9-TBG-cre which is expressed in hepatocytes

• diminished Ca2+ retention capacity indicating exacerbated permeability transition pore opening in liver mitochondria from mice injected with AAV9-TBG-cre

homeostasis/metabolism

decreased oxygen consumption ( J:367536 )

• ATP-coupled and maximal respiratory rates are decreased in liver mitochondria from mice injected with AAV9-TBG-cre

Genotype
MGI:8211166

cn2

• Allelic Composition: Myl2^tm1(cre)Krc/Myl2⁺; Romo1^tm1Xiwa/Romo1^tm1Xiwa
• Genetic Background: involves: 129S4/SvJae * C57BL/6

cellular

abnormal mitochondrial physiology ( J:367536 )

• oxidative shift in the cysteinome in mitochondria in the heart

• diminished Ca2+ retention capacity indicating exacerbated permeability transition pore opening in heart mitochondria

homeostasis/metabolism

decreased oxygen consumption ( J:367536 )

• ATP-coupled and maximal respiratory rates are decreased in heart mitochondria