Phenotypes associated with this allele

• Allele Symbol: Mmp9^em1Iimcb
• Allele Name: endonuclease-mediated mutation 1, Olga Gewartowska
• Allele ID: MGI:8209555
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp9^em1Iimcb/Mmp9^em1Iimcb	involves: C57BL/6 * CBA	MGI:8209576

Genotype
MGI:8209576

hm1

• Allelic Composition: Mmp9^em1Iimcb/Mmp9^em1Iimcb
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

slow extinction of fear memory ( J:364028 )

• enhanced freezing in fear-conditioning test owing to enhanced long-term fear memory

mortality/aging

mortality/aging ( J:364028 )

N • viable and normal survival

nervous system

abnormal dendritic spine morphology ( J:364028 )

• reduced length/head width ratio and smaller spine area in hippocampus CA1 region at age P28

• normal head width in hippocampus CA1 region at age P28

increased dendritic spine density ( J:364028 )

• in hippocampus CA1 region at age P28

decreased dendritic spine length ( J:364028 )

• in hippocampus CA1 region at age P28

enhanced long-term potentiation ( J:364028 )

• after high-frequency stimulation (HFS, 4 trains of 100 pulses at 100 Hz) in hippocampus CA1 neurons

• normal LTP in hippocampus CA1 neurons after stimulation with one 100 Hz pulse

reproductive system

reproductive system phenotype ( J:364028 )

N • fertile and normal litter size