Phenotypes associated with this allele

• Allele Symbol: Stat5b^em2Mam
• Allele Name: endonuclease-mediated mutation 2, Lothar Hennighausen
• Allele ID: MGI:8204545
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat5b^em2Mam/Stat5b^em2Mam	C57BL/6NCrl-Stat5b^em2Mam	MGI:8262802

Genotype
MGI:8262802

hm1

• Allelic Composition: Stat5b^em2Mam/Stat5b^em2Mam
• Genetic Background: C57BL/6NCrl-Stat5b^em2Mam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:365046 )

hematopoietic system

enlarged spleen ( J:365046 )

increased CD8-positive, alpha-beta T cell number ( J:365046 )

• in spleen and blood

• normal CD4-positive, NK and neutrophil cell numbers

increased central memory CD8 positive, alpha-beta T cell number ( J:365046 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:365046 )

increased regulatory T cell number ( J:365046 )

increased splenocyte number ( J:365046 )

immune system

enlarged spleen ( J:365046 )

increased CD8-positive, alpha-beta T cell number ( J:365046 )

• in spleen and blood

• normal CD4-positive, NK and neutrophil cell numbers

increased central memory CD8 positive, alpha-beta T cell number ( J:365046 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:365046 )

increased regulatory T cell number ( J:365046 )

increased splenocyte number ( J:365046 )

dermatitis ( J:365046 )

• ulcerative dermatitis from age 8 weeks

integument

dermatitis ( J:365046 )

• ulcerative dermatitis from age 8 weeks

neoplasm

neoplasm ( J:365046 )

N • no leukemia by age 2 months