Phenotypes associated with this allele

• Allele Symbol: Tasl^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:8203544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tasl^em1Bcgen/Tasl^em1Bcgen	BALB/cJ-Tasl^em1Bcgen	MGI:8204630

Genotype
MGI:8204630

hm1

• Allelic Composition: Tasl^em1Bcgen/Tasl^em1Bcgen
• Genetic Background: BALB/cJ-Tasl^em1Bcgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon level ( J:363059 )

• upon in vivo injection of TLR7 and TLR9 agonists, mice fail to produce type I interferons

• total splenocytes, total marrow, spleen plasmacytoid dendritic cells, B cells, and neutrophils cells fail to produce either IFN-beta or IL-6 upon TLR7/9 stimulation but respond normally to TLR4 stimulation

• however, injection of TLR4 agonist LPS results in no differences compared to wild-type mice and bone-marrow derived macrophages and dendritic cells show little to modest differences upon TLR stimulation

• stimulation of Flt3L-derived plasmacytoid dendritic cells with agonists for other innate immune receptors such as TLR3 (polyI:C), TLR4 (LPS), cGAS (ISD), and RIG-1 (5pdsRNA), shows no defects in IL-6 cytokine production

abnormal immune cell physiology ( J:363059 )

• mice and total splenocytes, total marrow, spleen plasmacytoid dendritic cells, B cells, and neutrophils cells lack responses to TLR7/9 stimulation

decreased susceptibility to systemic lupus erythematosus ( J:363059 )

• mice treated with imiquimod or pristane show no signs of systemic lupus erythematosus (SLE) phenotypes, indicating that mice are resistant to SLE development

• however, mice show no homeostatic differences in immune cell subsets within B cells, T cells, and myeloid cells under normal conditions

homeostasis/metabolism

decreased interferon level ( J:363059 )

• upon in vivo injection of TLR7 and TLR9 agonists, mice fail to produce type I interferons

• total splenocytes, total marrow, spleen plasmacytoid dendritic cells, B cells, and neutrophils cells fail to produce either IFN-beta or IL-6 upon TLR7/9 stimulation but respond normally to TLR4 stimulation

• however, injection of TLR4 agonist LPS results in no differences compared to wild-type mice and bone-marrow derived macrophages and dendritic cells show little to modest differences upon TLR stimulation

• stimulation of Flt3L-derived plasmacytoid dendritic cells with agonists for other innate immune receptors such as TLR3 (polyI:C), TLR4 (LPS), cGAS (ISD), and RIG-1 (5pdsRNA), shows no defects in IL-6 cytokine production