Tasl^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tasl^em1Bcgen
• Name: TLR adaptor interacting with endolysosomal SLC15A4; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:8203544
• Gene: Tasl Location: ChrX:84913960-84935105 bp, + strand Genetic Position: ChrX, 39.39 cM, cytoband B
• Alliance: Tasl^em1Bcgen page

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5-AAAATTATAAGAAGACGCTGTGG-3 and 5-AAGGCCTACCATTCCAGTGCAAG-3 targeting the intronic region and the 3UTR region deleted exon 2. (J:363059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tasl Mutation: 7 strains or lines available

References

• Original: J:363059 Lau L, et al., An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling. Nat Commun. 2025 Jan 24;16(1):968
• All: 1 reference(s)