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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpm4em1Hrd
endonuclease-mediated mutation 1, Edna C Hardeman
MGI:8192458
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tpm4em1Hrd/Tpm4em1Hrd involves: C57BL/6 MGI:8192687
ht2
 		Tpm4em1Hrd/Tpm4+ involves: C57BL/6 MGI:8192689


Genotype
MGI:8192687
hm1
Allelic
Composition		 Tpm4em1Hrd/Tpm4em1Hrd
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm4em1Hrd mutation (0 available); any Tpm4 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:242938 )
• mice exhibit macrothrombocytopenia




Genotype
MGI:8192689
ht2
Allelic
Composition		 Tpm4em1Hrd/Tpm4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm4em1Hrd mutation (0 available); any Tpm4 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:242938 )
• mice exhibit macrothrombocytopenia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory