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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mroh2btm1Mkob
targeted mutation 1, Moira K O'Bryan
MGI:8192116
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mroh2btm1Mkob/Mroh2btm1Mkob involves: C57BL/6 * CBA MGI:8192137
ht2
 		Mroh2btm1Mkob/Mroh2b+ involves: C57BL/6 * CBA MGI:8192138


Genotype
MGI:8192137
hm1
Allelic
Composition		 Mroh2btm1Mkob/Mroh2btm1Mkob
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mroh2btm1Mkob mutation (0 available); any Mroh2b mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage, complete penetrance ( J:236944 )
• no mice are obtained and no embryos are recovered at 10-16 dpc, indicating that embryos die before 10 dpc




Genotype
MGI:8192138
ht2
Allelic
Composition		 Mroh2btm1Mkob/Mroh2b+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mroh2btm1Mkob mutation (0 available); any Mroh2b mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:236944 )
• higher than expected ratio of heterozygotes to wild-type mice is seen; the skewing of the ratio occurs no matter which parent is heterozygote or if both are, without change in litter size, testes, or sperm concentration, viability or motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory