Mroh2b^tm1Mkob
Targeted Allele Detail

Summary

• Symbol: Mroh2b^tm1Mkob
• Name: maestro heat-like repeat family member 2B; targeted mutation 1, Moira K O'Bryan
• MGI ID: MGI:8192116
• Synonyms: DeltaSpif
• Gene: Mroh2b Location: Chr15:4928219-4991687 bp, + strand Genetic Position: Chr15, 1.98 cM, cytoband A1
• Alliance: Mroh2b^tm1Mkob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236944
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin cassette with an internal stop site replaced exons 7-15 via homologous recombination, preventing translation of the protein. (J:236944)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mroh2b Mutation: 103 strains or lines available

References

• Original: J:236944 Stanger SJ, et al., A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. FASEB J. 2016 Aug;30(8):2777-91
• All: 1 reference(s)