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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spag11aem2Mgef
endonuclease-mediated mutation 2, Mouse Genome Engineering Facility
MGI:8190590
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spag11aem2Mgef/Spag11aem2Mgef C57BL/6NJNcbs-Spag11aem2Mgef MGI:8190648
ht2
 		Spag11aem2Mgef/Spag11a+ C57BL/6NJNcbs-Spag11aem2Mgef MGI:8190647


Genotype
MGI:8190648
hm1
Allelic
Composition		 Spag11aem2Mgef/Spag11aem2Mgef
Genetic
Background		 C57BL/6NJNcbs-Spag11aem2Mgef
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag11aem2Mgef mutation (0 available); any Spag11a mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
hairpin sperm flagellum ( J:358528 )
• spermatozoa exhibit tail abnormalities, with bent and rounded tails
abnormal sperm head morphology ( J:358528 )
• spermatozoa exhibit head abnormalities, with tilted heads
spermatic granuloma ( J:363226 )
• foci of granuloma in the tubules of caput epididymis
abnormal epididymis epithelium morphology ( J:363226 )
• hyperplasia of mucosal epithelial cells and foci of granuloma in the tubules in the caput epididymis
• diethylnitrosamine (DEN)-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis
reduced male fertility ( J:358528 )
• homozygous males mated with wild-type females show reduced litter size and sperm count, indicating reduced male fertility
impaired acrosome reaction ( J:358528 )
• sperm shows failure of the acrosome reaction
• however, sperm capacitation appears normal

neoplasm
increased incidence of tumors by chemical induction ( J:363226 )
• DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis

immune system
spermatic granuloma ( J:363226 )
• foci of granuloma in the tubules of caput epididymis

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:363226 )
• DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis

cellular
hairpin sperm flagellum ( J:358528 )
• spermatozoa exhibit tail abnormalities, with bent and rounded tails
abnormal sperm head morphology ( J:358528 )
• spermatozoa exhibit head abnormalities, with tilted heads




Genotype
MGI:8190647
ht2
Allelic
Composition		 Spag11aem2Mgef/Spag11a+
Genetic
Background		 C57BL/6NJNcbs-Spag11aem2Mgef
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag11aem2Mgef mutation (0 available); any Spag11a mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
epididymis inflammation ( J:363226 )
• foci of inflammation are seen in the caput epididymis
abnormal caput epididymis morphology ( J:363226 )
• mild hyperplasia is seen in the caput epididymis
abnormal epididymis epithelium morphology ( J:363226 )
• diethylnitrosamine (DEN)-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis

neoplasm
increased incidence of tumors by chemical induction ( J:363226 )
• DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis

immune system
epididymis inflammation ( J:363226 )
• foci of inflammation are seen in the caput epididymis

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:363226 )
• DEN-treated mice exhibit mild to moderate mucosal epithelial cell hyperplasia, as well as dysplastic alternations in a few mucosal epithelial cells in the caput epididymis indicating a higher susceptibility towards chemically induced tumorigenesis of the caput epididymis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory