Phenotypes associated with this allele

• Allele Symbol: Capsl^em1Xjz
• Allele Name: endonuclease-mediated mutation 1, Xianjun Zhu
• Allele ID: MGI:8190488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Capsl^em1Xjz/Capsl^em1Xjz Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:8190490

Genotype
MGI:8190490

cn1

• Allelic Composition: Capsl^em1Xjz/Capsl^em1Xjz; Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal hyaloid artery morphology ( J:365043 )

• hyaloid vasculature in the retina at P10 shows delayed regression in tamoxifen-treated mice

abnormal retina vasculature morphology ( J:365043 )

• mice injected intraperitoneally with tamoxifen at P1 to P3 exhibit reduced radial vascular growth, vessel density, and vascular branching in the retina

• the number of retinal vascular tip cells is decreased and sparsely distributed in retina of tamoxifen-treated mice

abnormal retina blood vessel morphology ( J:365043 )

• tamoxifen-treated mice show delayed development of deep retinal vessels at P10 and P14 retina shows incomplete architecture of the deep vascular layer

• however, by P21, endothelial cell growth resembles control retinas when angiogenesis is almost complete

cardiovascular system

abnormal hyaloid artery morphology ( J:365043 )

• hyaloid vasculature in the retina at P10 shows delayed regression in tamoxifen-treated mice

abnormal retina vasculature morphology ( J:365043 )

• mice injected intraperitoneally with tamoxifen at P1 to P3 exhibit reduced radial vascular growth, vessel density, and vascular branching in the retina

• the number of retinal vascular tip cells is decreased and sparsely distributed in retina of tamoxifen-treated mice

abnormal retina blood vessel morphology ( J:365043 )

• tamoxifen-treated mice show delayed development of deep retinal vessels at P10 and P14 retina shows incomplete architecture of the deep vascular layer

• however, by P21, endothelial cell growth resembles control retinas when angiogenesis is almost complete

abnormal angiogenesis ( J:365043 )

• retinal angiogenesis is impaired in tamoxifen-treated mice, with reduced vascular progression, vessel density, vascular branching, number of tip cells, and number of filopodia

• however, no notable leakage in the retina, indicating an intact retinal vascular barrier

abnormal vascular regression ( J:365043 )

• tamoxifen-treated mice exhibit an increase in vascular regression in the retina, evidenced by an increase in collagen IV basal membrane sleeves lacking IB4 both in the capillary plexus and angiogenic front

abnormal vascular endothelial cell migration ( J:365043 )

• the nuclei of tip endothelial cells in the retina of tamoxifen-treated cells appear more spherical and do not orient toward the avascular area, indicating impaired polarity and migration of tip cells in the direction of vascular development

cellular

abnormal vascular regression ( J:365043 )

• tamoxifen-treated mice exhibit an increase in vascular regression in the retina, evidenced by an increase in collagen IV basal membrane sleeves lacking IB4 both in the capillary plexus and angiogenic front

abnormal vascular endothelial cell migration ( J:365043 )

• the nuclei of tip endothelial cells in the retina of tamoxifen-treated cells appear more spherical and do not orient toward the avascular area, indicating impaired polarity and migration of tip cells in the direction of vascular development

decreased endothelial cell proliferation ( J:365043 )

• retina shows reduced proliferation of endothelial cells in tamoxifen-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:365043