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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bnc1tm1.1Nju
targeted mutation 1.1, Model Animal Research Center of Nanjing University
MGI:8190270
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bnc1tm1.1Nju/Bnc1tm1.1Nju involves: C57BL/6NTac MGI:8190289
ht2
 		Bnc1tm1.1Nju/Bnc1+ involves: C57BL/6NTac MGI:8190286


Genotype
MGI:8190289
hm1
Allelic
Composition		 Bnc1tm1.1Nju/Bnc1tm1.1Nju
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bnc1tm1.1Nju mutation (0 available); any Bnc1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle number ( J:266539 )
• 36-week-old females exhibit decreased follicle numbers at every stage of the developing follicle, with mean numbers of total follicles in ovaries of 34.3 versus 207.7 in wild-type females
small ovary ( J:266539 )
• ovaries are smaller at 8 and 36 weeks of age
reduced female fertility ( J:266539 )
• females are unable to produce any offspring

endocrine/exocrine glands
abnormal ovarian follicle number ( J:266539 )
• 36-week-old females exhibit decreased follicle numbers at every stage of the developing follicle, with mean numbers of total follicles in ovaries of 34.3 versus 207.7 in wild-type females
small ovary ( J:266539 )
• ovaries are smaller at 8 and 36 weeks of age

homeostasis/metabolism
decreased circulating estradiol level ( J:266539 )
• females exhibit decreased estradiol levels at 36, but not 8, weeks of age
increased circulating follicle stimulating hormone level ( J:266539 )
• females exhibit higher follicle stimulating hormone levels at 36 weeks of age
increased circulating luteinizing hormone level ( J:266539 )
• females exhibit higher luteinizing hormone levels at 36 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
primary ovarian insufficiency 16 DOID:0080873 OMIM:618723
 J:266539




Genotype
MGI:8190286
ht2
Allelic
Composition		 Bnc1tm1.1Nju/Bnc1+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bnc1tm1.1Nju mutation (0 available); any Bnc1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle number ( J:266539 )
• 36-week-old females exhibit decreased follicle numbers at every stage of the developing follicle with mean numbers of total follicles in ovaries of 110.3 versus 207.7 in wild-type females
small ovary ( J:266539 )
• ovaries are smaller at 8 and 36 weeks of age

endocrine/exocrine glands
abnormal ovarian follicle number ( J:266539 )
• 36-week-old females exhibit decreased follicle numbers at every stage of the developing follicle with mean numbers of total follicles in ovaries of 110.3 versus 207.7 in wild-type females
small ovary ( J:266539 )
• ovaries are smaller at 8 and 36 weeks of age

homeostasis/metabolism
decreased circulating estradiol level ( J:266539 )
• females exhibit decreased estradiol levels at 36, but not 8, weeks of age
increased circulating follicle stimulating hormone level ( J:266539 )
• females exhibit higher follicle stimulating hormone levels at 36 weeks of age
increased circulating luteinizing hormone level ( J:266539 )
• females exhibit higher luteinizing hormone levels at 36 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
primary ovarian insufficiency 16 DOID:0080873 OMIM:618723
 J:266539




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory