Analysis Tools
growth/size/body
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• body weight is slightly higher in neonates at 5 days postpartum but not significantly different in adults
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behavior/neurological
| N |
• mice show no differences in muscular strength in the hanging wire or the automatized grip strength test, in the plus maze, in the novel object recognition test (normal recognition memory), in spontaneous alternation in the t-maze (normal spatial alternation learning), and in associative learning in the passive avoidance paradigm (normal associative learning)
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• 5-month-old mice show a decrease on parallel index, walking aberrantly less straight compared to wild-type mice
• while mice show reduced parallel index with age, it is no different from wild-type mice at 16 months of age
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• mice exhibit reduced motor coordination in the accelerating rotarod task
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hypoactivity
(
J:365556
)
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• 5-month-old mice exhibit decreased spontaneous locomotor activity in the open field, indicating hypoactivity
• while mice show reduced spontaneous locomotor activity with age, it is no different from wild-type mice at 16 months of age
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cardiovascular system
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• ventricular cardiomyocyte cross-sectional area is smaller in 6-month-old mice
• however, neonates exhibit normal cardiomyocyte number and area
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• cardiac dilatation at 6 months of age and ventricular dilation increases with age, particularly during diastole
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• mild
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• echocardiography shows increased left ventricular internal dimensions and a trend to reduced septum thickness
• a slight reduction in contractile function is seen, but not statistically significant, and percent fractional shortening is normal and heart rate is unaffected at 6 months of age
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muscle
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• ventricular cardiomyocyte cross-sectional area is smaller in 6-month-old mice
• however, neonates exhibit normal cardiomyocyte number and area
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• mild
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