Phenotypes associated with this allele

• Allele Symbol: Pla2g6^em1Susz
• Allele Name: endonuclease-mediated mutation 1, Katalin Susztak
• Allele ID: MGI:8187927
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g6^em1Susz/Pla2g6^em1Susz	Not Specified	MGI:8245387
cx2	Pla2g6^em1Susz/Pla2g6^em1Susz Tg(Pax8-rtTA2S*M2)1Koes/0 Tg(tetO-LACTB)#Susz/0	involves: C57BL/6 * DBA * SJL	MGI:8245393

Genotype
MGI:8245387

hm1

• Allelic Composition: Pla2g6^em1Susz/Pla2g6^em1Susz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

dilated renal tubule ( J:359729 )

• more severe dilation following cisplatin or folic acid induced kidney injury

abnormal kidney physiology ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function

• however, baseline function and morphology are similar to controls

homeostasis/metabolism

increased blood urea nitrogen level ( J:359729 )

• following injection with cisplatin or treatment with folic acid to induce kidney injury compared to treatment matched controls

• however, baseline BUN is similar to controls

increased susceptibility to injury ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function

cellular

abnormal mitochondrial physiology ( J:359729 )

• higher levels of oxidized phosphatidylethanolamine (PE) and lower levels of lyso-PE in cultured kidney tubule cells

Genotype
MGI:8245393

cx2

• Allelic Composition: Pla2g6^em1Susz/Pla2g6^em1Susz; Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-LACTB)#Susz/0
• Genetic Background: involves: C57BL/6 * DBA * SJL

renal/urinary system

abnormal kidney physiology ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function

• however, baseline function and morphology are similar to controls

homeostasis/metabolism

uremia ( J:359729 )

• marked azotemia following folic acid induced kidney damage

increased blood urea nitrogen level ( J:359729 )

• following injection with cisplatin or folic acid to induce kidney injury compared to treatment matched controls

• however, baseline BUN is similar to controls

increased susceptibility to injury ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function unlike mice with over-expression of LACTB alone