Tg(tetO-LACTB)#Susz
Transgene Detail

Summary

• Symbol: Tg(tetO-LACTB)#Susz
• Name: transgenic insertion, Katalin Susztak
• MGI ID: MGI:8187930
• Transgene: Tg(tetO-LACTB)#Susz Location: unknown
• Alliance: Tg(tetO-LACTB)#Susz page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-LACTB)#Susz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LACTB (114294)

  Lactb

  (MGI:1933395)

• Mutation details: A construct containing a tetracycline responsive element and human LACTB cDNA was inserted. Five founders were evaluated. (J:359729)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:359729 Li S, et al., Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. Cell Metab. 2024 Nov 14
• All: 1 reference(s)