Phenotypes associated with this allele

• Allele Symbol: Lactb^em1Susz
• Allele Name: endonuclease-mediated mutation 1, Katalin Susztak
• Allele ID: MGI:8187926
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lactb^em1Susz/Lactb^em1Susz	Not Specified	MGI:8245308

Genotype
MGI:8245308

hm1

• Allelic Composition: Lactb^em1Susz/Lactb^em1Susz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased kidney weight ( J:359729 )

• in males and females on a high fat diet compared to diet matched controls with a mild increase in fat deposition

abnormal renal tubule morphology ( J:359729 )

• in primary kidney tubule cells mitochondria are fragmented or characterized by a prominent rod-like shape with perturbed crista

dilated renal tubule ( J:359729 )

• mild dilation in males and females on a high fat diet

abnormal kidney physiology ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function

• in primary renal tubule cells mitochondrial respiration is impaired

• treatment with ferrostatin-1 alleviates the cisplatin induced kidney injury

homeostasis/metabolism

increased blood urea nitrogen level ( J:359729 )

• following injection with cisplatin or treatment with folic acid to induce kidney injury compared to treatment matched controls

• however, baseline BUN is similar to controls

increased fasting circulating glucose level ( J:359729 )

♀ • in females on a high fat diet

decreased circulating HDL cholesterol level ( J:359729 )

• in males and females on a high fat diet compared to diet matched controls

• however, no significant change in HDL or total cholesterol on a normal chow diet

increased circulating triglyceride level ( J:359729 )

♀ • higher serum but not liver triglycerides in females but not males on normal chow or high fat diet

impaired glucose tolerance ( J:359729 )

• in males and females

abnormal amino acid metabolism ( J:359729 )

• altered amino acid metabolism in cultured primary kidney cells

increased susceptibility to injury ( J:359729 )

• show increased susceptibility to cisplatin or folic acid induced kidney injury with more severe histological changes and greater elevation in markers of impaired function

cellular

abnormal mitochondrial morphology ( J:359729 )

• in primary kidney tubule cells mitochondria are fragmented or characterized by a prominent rod-like shape with perturbed crista

abnormal mitochondrial physiology ( J:359729 )

• in primary renal tubule cells mitochondrial respiration is impaired

• higher levels of oxidized phosphatidylethanolamine (PE) and lower levels of lyso-PE in cultured kidney tubule cells

growth/size/body

increased kidney weight ( J:359729 )

• in males and females on a high fat diet compared to diet matched controls with a mild increase in fat deposition