Lactb^em1Susz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lactb^em1Susz
• Name: lactamase, beta; endonuclease-mediated mutation 1, Katalin Susztak
• MGI ID: MGI:8187926
• Gene: Lactb Location: Chr9:66862668-66882706 bp, - strand Genetic Position: Chr9, 36.23 cM, cytoband D
• Alliance: Lactb^em1Susz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/cas9 mediated recombination created a null allele. Immunoblot analysis confirmed the absence of expression in kidneys from homozygous mice. (J:359729)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lactb Mutation: 23 strains or lines available

References

• Original: J:359729 Li S, et al., Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. Cell Metab. 2024 Nov 14
• All: 1 reference(s)