Phenotypes associated with this allele

• Allele Symbol: Znfx1^em1Xua
• Allele Name: endonuclease-mediated mutation 1, Anlong Xu
• Allele ID: MGI:8187911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Znfx1^em1Xua/Znfx1^em1Xua	involves: C57BL/6J	MGI:8187916

Genotype
MGI:8187916

hm1

• Allelic Composition: Znfx1^em1Xua/Znfx1^em1Xua
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:345967 )

• decreased levels of CD80, CD86, and MHC-II in bone marrow derived macrophages in response to H37Rv infection

• however, expression of IL1B, IL6, or TNF-alpha are similar to controls in response to H37Rv infection

impaired macrophage phagocytosis ( J:345967 )

• bone marow derived macrophages show reduced phagocytic activity when challenged with H37Rv labeled with RFP or when incubated with FITC-latex beads

decreased macrophage cytokine production ( J:282875 )

• isolated bone marrow derived macrophages show reduced IFNalpha and beta secretion after RNA virus infection by vesicular stomatitis virus, encephalomyocarditis virus, or H1N1 influenza A virus but not herpes simplex virus type 1

decreased circulating interferon-gamma level ( J:345967 )

• decreased in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

decreased circulating interleukin-12 level ( J:345967 )

• decreased in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

decreased circulating tumor necrosis factor level ( J:345967 )

• decreased TNF in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

decreased interferon-alpha secretion ( J:282875 )

• isolated bone marrow derived macrophages show reduced IFNalpha and beta secretion after RNA virus infection by vesicular stomatitis virus, encephalomyocarditis virus, or H1N1 influenza A virus but not herpes simplex virus type 1

• enhanced replication of VSV in the lung and liver and reduced secretion of IFNA and IFNB following infection through the caudal vein

decreased interferon-beta secretion ( J:282875 )

• isolated bone marrow derived macrophages show reduced IFNalpha and beta secretion after RNA virus infection by vesicular stomatitis virus, encephalomyocarditis virus, or H1N1 influenza A virus but not herpes simplex virus type 1

• enhanced replication of VSV in the lung and liver and reduced secretion of IFNA and IFNB following infection through the caudal vein

abnormal response to infection ( J:282875 )

• isolated bone marrow derived macrophages show reduced IFNalpha and beta secretion after RNA virus infection including by vesicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), or H1N1 influenza A virus but not herpes simplex virus type 1 (HSV1)

• isolated bone marrow derived macrophages show elevated viral mRNA levels after RNA virus infection including by VSV, EMCV, or H1N1 but not HSV1

• isolated MEFs show reduced IFN-beta secretion after RNA virus infection including by vesicular stomatitis virus or encephalomyocarditis virus

increased susceptibility to bacterial infection ( J:345967 )

• elevated bacterial loads following M. tuberculosis infection, marked tissue damage in the lungs, and inflammatory infiltration in both the lungs and spleen

• suppressed production of bactericidal NO following M. tuberculosis infection

• intracellular multiplication of M. tuberculosis in bone marrow derived macrophages is enhanced

increased susceptibility to Riboviria infection ( J:282875 )

• one day after VSV infection 80% of mice display conjunctivitis

• enhanced replication of VSV in the lung and liver and reduced secretion of IFNA and IFNB following infection through the caudal vein

• increased infiltration of inflammatory cells into the lungs following VSV infection and decreased resistance in overall survival assays

homeostasis/metabolism

impaired autophagy ( J:345967 )

• markedly repressed in bone marrow derived macrophages

decreased circulating interferon-gamma level ( J:345967 )

• decreased in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

decreased circulating interleukin-12 level ( J:345967 )

• decreased in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

decreased circulating tumor necrosis factor level ( J:345967 )

• decreased TNF in the peripheral blood and in the lung and spleen at 1 week after M. tuberculosis infection

cellular

impaired autophagy ( J:345967 )

• markedly repressed in bone marrow derived macrophages

impaired macrophage phagocytosis ( J:345967 )

• bone marow derived macrophages show reduced phagocytic activity when challenged with H37Rv labeled with RFP or when incubated with FITC-latex beads

hematopoietic system

abnormal macrophage physiology ( J:345967 )

• decreased levels of CD80, CD86, and MHC-II in bone marrow derived macrophages in response to H37Rv infection

• however, expression of IL1B, IL6, or TNF-alpha are similar to controls in response to H37Rv infection

impaired macrophage phagocytosis ( J:345967 )

• bone marow derived macrophages show reduced phagocytic activity when challenged with H37Rv labeled with RFP or when incubated with FITC-latex beads

decreased macrophage cytokine production ( J:282875 )

• isolated bone marrow derived macrophages show reduced IFNalpha and beta secretion after RNA virus infection by vesicular stomatitis virus, encephalomyocarditis virus, or H1N1 influenza A virus but not herpes simplex virus type 1