Znfx1^em1Xua
Endonuclease-mediated Allele Detail

Summary

• Symbol: Znfx1^em1Xua
• Name: zinc finger, NFX1-type containing 1; endonuclease-mediated mutation 1, Anlong Xu
• MGI ID: MGI:8187911
• Gene: Znfx1 Location: Chr2:166877713-166904926 bp, - strand Genetic Position: Chr2, 87.22 cM
• Alliance: Znfx1^em1Xua page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs created a deletion spanning exons 3 through 11. (J:282875)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znfx1 Mutation: 106 strains or lines available

References

• Original: J:282875 Wang Y, et al., Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Nat Cell Biol. 2019 Nov;21(11):1346-1356
• All: 3 reference(s)