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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fam171a2em1Yjt
endonuclease-mediated mutation 1, Jin-Tai Yu
MGI:8187547
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fam171a2em1Yjt/Fam171a2em1Yjt involves: C57BL/6J MGI:8187591
ht2
Fam171a2em1Yjt/Fam171a2+ involves: C57BL/6J MGI:8187595


Genotype
MGI:8187591
hm1
Allelic
Composition
Fam171a2em1Yjt/Fam171a2em1Yjt
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam171a2em1Yjt mutation (0 available); any Fam171a2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lethality of homozygotes, no details provided




Genotype
MGI:8187595
ht2
Allelic
Composition
Fam171a2em1Yjt/Fam171a2+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam171a2em1Yjt mutation (0 available); any Fam171a2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following intrastriatal injection of recombinant alpha-synuclein preformed fibrils loss of TH-positive neurons and fiber degeneration is reduced compared to similarly treated wild-type controls
• performance in behavioral assays (pole test, rotarod test, and wire hang test) following intrastriatal injection of recombinant alpha-synuclein preformed fibrils is similar to wild-type controls

nervous system
• reduced accumulation of recombinant alpha-synuclein preformed fibrils following intrastriatal injection compared to similarly treated wild-type controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory